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1 Introduction Rosacea is a chronic inflammatory dermatosis characterized by centrofacial erythema, telangiectasia, papulopustular lesions, and phymatous changes ( Rosacea classification has transitioned from a fixed subtype-based system to a flexible phenotype-driven approach

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7 These pretreatment doses and times were selected based on other previous studies 1 , 7 and preliminary experiments in which the safety after injection was determined, since we used rats as the experimental animals