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Characteristic changes in mitochondria, such as increased inner membrane density, loss of mitochondrial cristae, and mitochondrial atrophy have been observed in almost all ferroptotic cells 61
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408 In line with this hypothesis, the loss of NAPRT in both RCC cell lines and EMT-subtype gastric cell lines renders the cells hypersensitive to NAMPT inhibitors, such as FK866, and KPT-9274, suggesting that NAMPT inhibitors may be a promising strategy for NAPRT deficient tumors
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