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Four important considerations arise from the reaction involving a sulfuranyl free radical: 1) The free radical formed on S-atom of Met35 of Aβ42 is likely due to one or both of two sources: i ) As discussed above, because of its zero-dipole moment, molecular oxygen is present in large concentrations in the lipid bilayer (FIGURE 4)

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Altered expression of insulin-degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E-epsilon4-associated Alzheimer’s disease