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Merestinib (LY2801653, Eli Lilly and Company, Indianapolis, Indiana, USA) is an orally bioavailable c-MET inhibitor that targets several other kinases like RON, FLT3, AXL, MER proto-oncogene tyrosine kinase (MERTK), TIE-2, ROS1, neurotrophic tropomyosin receptor kinase (NTRK) 1/2/3, discoidin domain receptor 1 and 2 (DDR1/2), and MAP kinase interacting serine/threonine kinase 1 and 2 (MKNK1/2) [118, 119], and is currently under early phases of clinical development (NCT02920996)
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In worms, an increase in O 2 •− specifically protected against oxidative stress and lengthened the lifespan of isp-1 and nuo-6 mutants (93)
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