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In addition, a statistically significant reduction in CYP1A2 and CYP3A4 was observed after the administration of the NAC + VitD3 + Glut
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Amino acid metabolism, particularly dysregulation of the tryptophan-kynurenine (Trp-Kyn) pathway, is also involved in immune tolerance mechanisms through the suppression of M1 macrophages and CD4+T helper 1 (Th1) cells and the expansion of regulatory T cells (Tregs), with potential implications for disease progression and therapeutic intervention (23)
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