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In a retrospective study evaluating the association between MRS and the grading of glioma, it was found that NAA/Cho and NAA/Cr were negatively associated and Cho/Cr was positively associated with pathological grading in patients with glioma (9)
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Its use in medicine goes back to the 19th century when Alfred Baring Garrod (1819-1909) used lithium salts to treat gout and uric acid stones
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