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In fact, EMT is a result of phenotypic and metabolic plasticity induced by the ZEB1–NNMT axis ( CTGF promoter methylation ( The Crosstalk Between Tumor Metabolism and Epigenetics Accumulating evidence has shown that, in cancer, cellular metabolism can also have a profound impact on signaling and transcriptional networks via different mechanisms ( NNMT Regulates NAD + Metabolism to Influence Deacetylases In addition to metabolism remodeling, epigenomic reprogramming is another main consequence of NNMT overexpression
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