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Studies have also shown that the transfer of MSC results in a notable improvement in the clinical results of MS in experimental models of EAE (de Witte et al., 2018
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The a1/a2 domains are essential for binding semaphorins, such as sema3A, involved in axonal guidance, while the b1 domain allows high-affinity binding to VEGF-A165 in NRP1 and to VEGF-C in NRP2, with the b2 domain enhancing these interactions
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