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In ferroptosis, polyunsaturated fatty acids (PUFAs) within membrane phospholipids undergo peroxidation, causing oxidative damage that compromises membrane integrity and leads to cell death
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These studies demonstrate that chronic ethanol consumption results in dramatically increased levels of CYP2E1 (up to 20-fold) leading to increased production of reactive oxygen species (ROS), lower cellular antioxidant levels, and enhanced oxidative stress
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