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NADPH is the major reducing agent of the cell, and its abundance is dependent on the complex interaction between metabolic pathways that control fundamental life processes including energy production, molecule synthesis and antioxidant defence
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Cardiac Toxicity Oxidative stress and activation of the inflammatory pathway via NFκβ, with the simultaneous release of pro-inflammatory cytokines (IL-2, IL-10, IL-6, and TNF-α) associated with acrolein, induces hypertrophy, myocardial fibrosis, and arrhythmogenesis [163]
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