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Treatment of mice with oral melatonin (50 or 100 mg/kg) 4 or 8 hours before acetaminophen overdose suppressed the increase in serum ALT and AST activities in a dose- and a time-dependent manner, but had no effect on liver glutathione levels
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In this context, the Nrf2/Keap1 transcription complex in animals is the primary finely tuned system that regulates the expression of many oxidative stress-related genes, including antioxidant and phase II detoxification enzymes
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