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Human milk-derived lactoferrin is able to mature CD4 − CD8 − murine T-cells, with a preference towards expression of CD4 [49], primarily through induced intracellular MAP kinase pathways via Erk2 and a requirement for p56 lck (kinase specific to lymphocytes) [147]
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In melanoma, the frequent suppression of this pathway through epigenetic and enzymatic mechanisms facilitates tumor cell survival and immune evasion, highlighting the importance of understanding and potentially restoring necroptotic signaling for therapeutic benefit ( Figure 3 )
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