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Frontiers | Bee venom ameliorates gentamicin-induced kidney injury by restoring renal aquaporins and enhancing antioxidant and anti-inflammatory activities in rats
doi: 10.1210/en.2019-00487 50 KurowskaPMlyczyńskaEDawidMJurekMKlimczykDDupontJet al
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The synthesis of GPX4 begins with cystine being transported into cells via the system Xc⁻ transporter, a heterodimer of SLC7A11 and SLC3A2 embedded in the cell membrane, followed by intracellular conversion of cystine to cysteine, which combines with glutamate and glycine to form glutathione (GSH) which serves as the substrate for GPX4, a selenoprotein that utilizes its intrinsic GSH to reduce cytotoxic lipid hydroperoxides into non-toxic lipid alcohols, thereby inhibiting ferroptosis [93, 94]
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