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Two critical factors/conditions seem to determine this selectivity of vitamin C-mediated cancer cell killing: (1) the selective accumulation of DHA in cancer cells via a GLUT1-dependent transport mechanism, leading to intracellular GSH depletion and ROS accumulation, and (2) ROS-mediate inhibition of the glycolytic enzyme GAPDH in the background of oncogene-induced metabolic reprogramming (i.e., dependence on glycolysis for survival), resulting in ATP depletion and cell death
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Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma
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