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the disease does not change volume of distribution but increases total clearance because more free drug (not bound to protein) is present
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However, when the researchers exposed the mice to a mutagen to establish lung cancer, they observed more rapid cancer development in the TertKI mice compared to control animals, suggesting that the overexpression of TERT “can increase the likelihood of carcinogenesis under chronic harmful stimulation.” Testing whether the genetic modification and TERT overexpression would cause any DNA damage or disturb fetal growth or development revealed no differences between genetically modified and wild-type mice
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