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Similarly, exposure of primary microglial cells to recombinant aggregated or mutated alpha-synuclein results in increased activated microglia and ROS production followed by the secretion of TNF-alpha, IL6 and IL-1beta [266, 272, 273] and the activation of intracellular pathways such as ERK1/2 and p38 MAPK [272]
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C57BL /6 mice that underwent adoptive cell transfer of GP x8‐deficient macrophages displayed a similar phenotype of enhanced colitis, indicating a critical role of GP x8 in macrophages
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