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This fluctuating oxygen tension, combined with iron availability and inflammatory mediators, further amplifies lipid peroxidation potential (95, 96) In reconstruction contexts involving staged procedures—such as the induced membrane technique or serial debridement for infected defects—repeated surgical insults may perpetuate this cycle of ischemia–reperfusion and oxidative stress (97, 98)

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B12 helps convert one compound (homocysteine) into another (methionine), which the body uses to create materials necessary for repair and cellular signaling