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Glossary Abbreviations Used 19C* 19-carboxy-nonadecanoic acid γGlu γ-glutamic acid Aad ( S )-2-aminohexanedioic acid Acm acetamidomethyl Alloc allyloxycarbonyl AMYR amylin receptor AMY 3 R AMYR subtype 3 COMU (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate CTR calcitonin receptor DIO diet-induced obesity DIPEA N , N -diisopropylethylamine DLS dynamic light scattering DODT 3,6-dioxa-1,8-octanedithiol GLP-1 glucagon-like peptide 1 hAMY 3 R human AMY 3 R HCl hydrochloric acid hCTR human CTR HCTU O -(1 H -6-chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate HEPES 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, Hyp, (2 S ,4 R )-4-hydroxypyrrolidine-2-carboxylic acid N-Me Gly N -methylglycine (sarcosine) N-Me Ile N -methylisoleucine NaCl sodium chloride NaOH sodium hydroxide ND not detected OAII allyl ester pEC 50 negative logarithm of the half maximal effective concentration pI isoelectric point pos position RA receptor agonist RAMP receptor-activating modifying protein ref reference peptide RAMP3 RAMP subtype 3 RP reversed-phase SD Sprague–Dawley SE standard error of the mean SEC size exclusion chromatography ThT thioflavin T Tl(TFA) 3 thallium(III) trifluoroacetate UPLC ultraperformance liquid chromatography Restrictions apply to the availability of some or all data generated or analyzed during this study

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