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When NF-kB activity is elevated, cells may produce more inflammatory signals such as TNF-alpha, IL-6, IL-8, and related mediators
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Such IFN signatures have also been found to be increased in other myositis subtypes, even in inclusion body myositis (132), raising concerns not only about their specificity but also about the primary role of interferon types 1 and 2 in the pathomechanism of inflammatory myopathies, as proposed by others
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