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The reversible oxidation/reduction changes in these redox-sensing proteins lead to downstream metabolic and signaling events, for example, modulation of cellular metabolism and synaptic plasticity through activation/deactivation of a variety of signaling effectors, such as kinases, phosphatases and transcription factors (e.g., Nrf2 and NF-ฮบB) (Arrigo, 1999 )
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