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[DOI] [PubMed] [Google Scholar] 101.Hunter A.A., Smit-McBride Z., Anderson R., Bordbari M.H., Ying G.S., Kim E.S., Park S.S., Telander D.G., Dunaief J.L., Hjelmeland L.M., et al

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GAA is an aldosterone-type triterpenoid derived from Ganoderma lucidum, known for its antioxidant, anti-inflammatory, antidepressant, and anticancer properties ( In vitro experiments confirmed that Aβ 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury