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Specifically, HIF suppressed carnitine palmitoyltransferase 1A (CPT1A) and medium-chain acyl-CoA dehydrogenase (MCAD), leading to impaired fatty acid β-oxidation and enhanced lipid droplet deposition (122)
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Among them, DNL201, a CNS-penetrant LRRK2 inhibitor, has been shown in preclinical studies to effectively reduce LRRK2 activity and restore lysosomal function
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