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After the acute repletion phase, therapy is usually transitioned to an oral maintenance multivitamin containing a physiological dose of pyridoxine (2-5 mg daily) for several weeks, along with dietary counseling to prevent recurrence

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Other patterns of drugs co-used with tianeptine that merit further attention are the psychostimulant modafinil, commonly used to treat sleep disorders, and the NMDA antagonist memantine, which is a primarily used to treat symptoms of Alzheimer’s disease, both of which have been used or misused nonmedically [57–59]