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Drugs used to treat peripheral neuropathy include pain relievers, anticonvulsants, antidepressants, and local anesthetics, but these just alleviate the symptoms to some extent regardless of the actual mechanism of neuropathy [11]
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While the reactions of H 2 S with some oxidants display relatively high rate constants, comparable to those of LMW thiols, the tissue concentrations of H 2 S (submicromolar, see section 3.5) are very low, i.e., several orders of magnitude lower than those of other reductants (e.g., millimolar for some thiols)
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