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Furthermore, studies performed in endothelial cells, Kaposi’s sarcoma-associated herpesvirus (KSHV)-transformed cancer cells and several normal fibroblast or epithelial cell lines reported a similar effect of asparagine on supporting cell survival and protein translation after glutamine deprivation 44,49,50
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In fact, GR and FK506 binding protein 5 (FKBP5) expression can be changed by the polyphenolic flavonoid icariin, which enhances GR stability and lessens GR sensitivity to GC in vivo (167)
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