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Surprisingly, given the importance of hypoxia on radiation sensitivity, studies investigating the effect of ionizing radiation on the HIF1 pathway are sparse, but there is some evidence that ionizing radiation activates the HIF-1 pathway in cancer cells 375,376
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333 The 9,12-, 13,16-, and 9,16-dihydroperoxides may be formed from the 9- and 16-hydroperoxides by the same mechanism suggested for autoxidized methyl linoleate that proceeds through pentadienyl radicals
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