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Keywords: Bilirubin, UDP-glucuronosyltransferase 1A1, humanized UGT1 mice, extra hepatic Introduction Bilirubin is the terminal metabolite of heme catabolism, is metabolized solely by UDP-glucuronosyltransferase (UGT) 1A1 through glucuronidation (Bosma et al., 1994), and accumulates in newborns because of a developmental delay in the expression of the UGTs (Burchell et al., 1989)
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