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Furthermore, specific non-pharmacological strategies, notably neuromodulation, may provide relief, particularly in cases where conventional treatments have been ineffective

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Congenital methemoglobinemia arises from globin mutations that stabilize iron in the ferric state (e.g., HbM Iwata [α 87His→Tyr ], Table 127-3) or from mutations that impair the enzymes that reduce methemoglobin to hemoglobin (e.g., methemoglobin reductase, NADP diaphorase)