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At later time points after 2/3 PH, upregulation of miR141-3p possibly mediates LR termination by inhibiting the Cdk8 gene, while p53-induced upregulation of miR34a exerts the same effect through the activation of the pro-apoptotic p53/miR34a/SIRT1 positive loop
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Along with this, ER stress due to the UPR may impair calcium transport from the ER to the mitochondria, resulting in increased levels of calcium release from the ER
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