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Notably, there is one other recently published study which showed that mice treated with 4-NQO and ovalbumin, which induces a Th2 response that leads to increased eosinophilic infiltration, had reduced severity of ESCC as compared with mice treated with 4-NQO alone.[32] We were the first to show the direct cytotoxic effect of ROS on pre-cancer cells in a co-culture modeling system, though ROS have been previously implicated as an anti-tumorigenic mechanism
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