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Relative to the baseline arm, kratom exposure had no effect on vital signs of the 12 participants (heart rate, blood oxygen saturation, and blood pressure
Local Anesthetic
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For scale, in the STEP 1 trial semaglutide 2.4 mg produced a mean weight loss of 14.9% versus 2.4% with placebo at 68 weeks (Wilding et al., NEJM 2021), which is trial-grade evidence for weight loss, not for back pain
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