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When reviewing CoAs for peptide drugs without USP drug monographs, it is important to be aware that “free base” vs “acetate” may come down to nomenclature issues and not true material difference

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As discussed above, unlike Y37 rAmy , P37 Cagri does not interact directly with RAMP1 or RAMP3, which likely decreases the stability of the ECD interface, leading to increased dynamics relative to the rAmy-bound AMY 1 R and rAmy-bound AMY 3 R (Fig