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A greater understanding of the role and mechanisms by which eosinophils can drive this very common endotype of asthma, focusing on aspects of metabolic function will provide a step-change in our understanding of how an altered metabolic phenotype in eosinophils contributes to their persistence in disease by altering the temporal activation of apoptosis and will determine the preference for the source of fuel (glucose, fatty acids or nucleotides) used to generate ATP under basal and stressor conditions
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