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While a full discussion of the tumor microenvironment, and in particular the role of the innate and adaptive immune system, is beyond the scope of this review, we highlight several features of the stromal microenvironment that can facilitate the survival of drug-tolerant cells by modulating tumor intrinsic survival pathways

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Extending the accepted nomenclature used in the mammalian GSTs, these are termed the phi, zeta, tau and theta classes (Figure 1)