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It reduces Cu²⁺ to the more reactive Cu⁺ and concurrently supplies electrons for the biosynthesis of the lipoyl moiety on key mitochondrial enzymes, such as Dihydrolipoamide Acetyltransferase (DLAT) [54]

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However, inhibition of microglial activity has also been reported to reduce post-stroke BBB dysfunction (Yenari et al., 2006)