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Importantly, the algorithm can predict putative peptide antigens that indeed trigger an efficient antitumor immune response after vaccination in preclinical glioblastoma models (186)
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C-X-C motif chemokine ligand (CXCL), a typical chemokine, can recruit immune cells to infiltrate the cerebrovascular system and brain parenchyma before initiating a variety of pathways leading to neuronal death (67)
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