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The canonical Wnt pathway depends on intracellular β-catenin, whose signal transduction cascade components in the hair follicle include Wnt proteins, frizzled receptors and the co-receptor low-density lipoprotein receptor (LRP)5/6, disheveled proteins, the multicomponent degradation complex [comprising Axin, casein kinase (CK)1α, adenomatous polyposis coli (APC) and GSK3β], β-catenin and transcription factor (TCF)/LEF (21)
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