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In November 2022, the FDA declared NMN could no longer be sold as a dietary supplement, because it had been investigated as a drug first (Metro International Biotech's pharmaceutical-grade candidate, MIB-626, now in Phase II).[15][17] That left NR — which holds self-affirmed GRAS status since 2016 and two favorable New Dietary Ingredient notifications — as the cleanly legal, well-documented oral precursor.[17] Then came the twist: after a multi-year fight led by the Natural Products Association, the FDA reversed course, and as of late 2025 reinstated NMN's status, permitting it once again as a supplement.[16] So the accurate 2026 picture — often reported out of date — is that both NR and NMN are lawfully available, with NR carrying the longer regulatory track record